DOI: https://doi.org/10.15574/PP.2016.66.65

Внутриутробные инфекции — причина патологических состояний перинатального периода

M. O. Shcherbina, L. A. Vigovskaya, N. V. Kapustnik

Аннотация


В последние годы обращает на себя внимание рост внутриутробных инфекций, которые являются причиной всего спектра антенатальной патологии: инфекционных заболеваний плода, пороков его развития, мертворождений, недоношенности, развития фетоплацентарной недостаточности и задержки внутриутробного развития плода. Отмечена роль инфекций в патогенезе патологических состояний, формирующихся в перинатальном периоде, у новорожденных. В развитии инфекционных поражений плода, тяжести заболевания, локализации патологического процесса, темпах реализации и проявлениях возникшей патологии имеют значение вид возбудителя, его вирулентность, пути проникновения микроорганизмов от матери к плоду. В обзоре представлены данные влияния внутриутробных инфекций на эмбрион, плод, течение и исход беременности, а также состояние новорожденного.

Ключевые слова: внутриутробные инфекции, внутриутробное инфицирование, плод, беременность, течение.


Ключевые слова


внутриутробные инфекции; внутриутробное инфицирование; плод; беременность; течение

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Литература


Azimova EI, Sultanov SN, Nishanova FP. 2011. On the issue of prevention of recurrence of genital herpes in pregnant women with antenatal fetal death in anamnesis. 2: 238—240.

Beznoshhenko GB, Dolgih TI, Krivchik GV. 2013. Intrauterine infection: (questions of diagnostics and medical tactics. Moskow: Medkniga; N.Novgorod: NGMA: 88.

Borovkova EI. 2013. The interaction of pathogens with the body of the pregnant woman as a risk factor for intrauterine fetal infection. 2: 95—98.

Bulavenko OV. 2012. Perinatal consequences of prenatal infection. Svit medytsyny ta biolohii. 4: 142—144.

Vedoshchenko TV, Klycheva OI, Lazareva GA, Khuraseva AB. 2014 Influence of growing bacterial infection on miscarriage. Chelovek i ego zdorov'e. 1: 49—51.

Podzolkova NM, Skvorcova MJu, Mel'nikova NI, Ostrejkov IF. 2009. Intrauterine infection: modern problems. Akusherstvo i ginekologija. 3: 27—32.

Khamadyanov UR, Rusakova LA, Khamadyanova AU et al. 2013. Intrauterine fetal infection: the present view of the problem. Rossiyskiy vestnik akushera-ginekologa. 5: 16—20.

Zaplatnikov AL, Korovin NA, Korneva MYu et al. 2013. Intrauterine infection: diagnosis, treatment, prevention. 1: 14—20.

Tkachenko IuP, Lezhenko HO, Reznichenko IuH et al. 2012. Intrauterine infection. Epidemiology, clinic, diagnostics and modern principles of therapy in pregnant women and children. Doneck: Zaslavskij A.Ju.: 141.

Tirskaya YuI, Belkova TN, Rudakova EB et al. 2012. Medical tactics at pre-natal infections. Akusherstvo i ginekologija. 8: 42—47.

Greenough A, Osborne J, Sutherland S (eds.). 2000. Congenital, perinatal and neonatal infections. Moscow: Meditsina: 288.

Hlazkov IS. 2000. Features of the functional state of the fetoplacental while herpes infection. Bukovynkyi medychnyi visnyk. 3: 44—47.

Gomberg MA. 2011. Reproductive health and genital chlamydial infection. Ginekologija. 1: 13—16.

Davydova IV. 2013. Prevention of perinatal infection and its consequences in pregnant women. Reproduktivnaja jendokrinologija. 3: 17—35.

Dolgoshapko ON. 2010. The role and place of anaerobic infections in the development of obstetric-gynecologic diseases, its treatment and prevention. Zdorov'e zhenshhiny. 10: 41—43.

Zhabchenko IA. 2013. Features of functioning and factors of virulence of uropathogenic stamms of Esherichia coli and their value in clinical practice. Zdorov'e zhenshhiny. 1: 114—116.

Makarova OV, Aleshkina VA, Savchenko TN et al. 2009. Infectious Diseases in Obstetrics and Gynecology. Moscow: MEDpress-inform: 464.

Kvashnina LV, Shunko E E, Matvienko IN. 2015. Children of the first years of live: basic indicators in the context of achieving the Millennium Development Goals in Ukraine. Part I. Perinatologiya i pediatriya. 4: 69—73.

Kuz'min VN, Adamjan LV. 2005. Viral infections and pregnancy. Moscow: Dipak: 176.

Lekhan VM, Ginzburg VG. 2012. Perinatal mortality in Ukraine: achievements and problems. Ukraina. Zdorovia natsii. 1: 15—25.

Likhachova AS, Redko II, Likhachova NV. 2013. Mixed-TORCH-infections assosiated with acute inborn viral infections and sexually transmissed infections. Tavricheskij mediko-biologicheskij vestnik. 2: 121—124.

Makacarija AD, Dolgushina NV. 2002. Herpetic infection. Antiphospholipid syndrome and fetal loss syndrome. Moscow: Triada-H: 80.

Makarov OV, Kovalchuk LV, Gankovskaya LV et al. 2007. Miscarriage, infection, innate immunity. Moscow: GJeOTAR-Media: 175.

Nezgoda II, Onofriychuk ES, Shchur VV. 2011. Perinatal and clinico-epidemiological aspects of cytomegalovirus infection. Perinatologiya i pediatriya. 2: 16—18.

Dar'ina MG, Tehova IG, Movchan KN et al. 2015. Unsolved problems of statistical data on intrauterine infections. Medicinskij al'manah. 5: 71—74.

Baranovskaja EI, Zhavoronok SV, Suprun LJa, Voroneckij AN. 2004. The course of pregnancy and delivery in patients with herpesvirus infections. Akusherstvo i ginekologija. 5: 49—50.

Pavlov OG. 2010. System analysis of newborns infections reasons in early neonatal period. Vestnik novyh medicinskih tehnologij. 3: 74—75.

Zhiljaev NI, Vasil'eva NA, Zhiljaev NN et al. 2011. Perinatal infection. Ternopol': 320.

Prilepskaja VI, Fofanova IJu. 2007. Mycoplasma infection and pregnancy. Akusherstvo i ginekologija. 4: 5—8.

Prokopjuk VJu. 2008. Mycoplasmosis in obstetrics and gynecology practice. Medicinskie aspekty zdorov'ja zhenshhiny. 5: 61—65.

Vorobyova ІI, Skripchenko NY, Chernenko TS et al. 2014. Prevention of intrauferine in fection and pregrancy maintining in women with reproductive losses in anamnesis. Neonatolohiia, khirurhiia ta perynatalna medytsyna. 2: 137—140.

Stepanenko VI, Ivanov SV. 2012. Modern therapeutic correction of the secondary immunodeficiency with medical nanotecgnology in the complex treatment of patients with urogenital infections. Zdorov'e zhenshhiny. 8: 171—177.

Stepankovskaja GK., Priluckaja AB. 2010. A modern approach to the treatment of vulvovaginal candidiasis in pregnant women. Zdorov'e zhenshhiny. 9: 80—82.

Fofanova IJu. 2007. Features of pregnancy in the presence of urogenital mycoplasmas. Ginekologija. 2: 67—70.

Hrjanin AA, Stecjuk OU, Andreeva IV. 2012. Chlamydia infection in gynecology and midwifery: the tactics of conducting patients in accordance with the contemporary recommendations in Russia and abroad. Lechashhij vrach. 3: 30—37.

Chajka VK. 2006. Infections in obstetrics and gynecology. Doneck: OOO «Al'mateo»: 640.

Jur'ev SJu. 2006. Mechanisms of formation of complications of pregnancy on the background of urogenital chlamydia trachomatis (PhD Thesis). Tomsk: 43.

Subramaniam A, Abramovici A, Andrews WW, Tita AT. 2012. Antimicrobials for preterm birth prevention: an overview. Infect Dis Obstet Gynecol: 157—159. http://dx.doi.org/10.1155/2012/157159

Ueno T, Niimi H, Yoneda N et al. 2015. Eukaryote-Made Thermostable DNA Polymerase Enables Rapid PCR-Based Detection of Mycoplasma, Ureaplasma and Other Bacteria in the Amniotic Fluid of Preterm Labor Cases. PLoS One. 10: e0129032. http://dx.doi.org/10.1371/journal.pone.0129032; PMid:26042418 PMCid:PMC4456152

Li DK, Raebel MA, Cheetham TC et al. 2014. Genital herpes and its treatment in relation to preterm delivery. Am J Epidemiol. 180(11): 1109—1117. http://dx.doi.org/10.1093/aje/kwu242; PMid:25392064

Guerra B, Puccetti C, Cervi F. 2012. The genital herpes problem in pregnancy. G Ital Dermatol Venereol. 147(5): 455—66. PMid:23007251

Howie SE, Horner PJ, Horne AW. 2011. Chlamydia trachomatis infection during pregnancy: known unknowns. Discov Med. 12(62): 57—64. PMid:21794209

Keegan MB, Diedrich JT, Peipert JF. 2014. Chlamydia trachomatis Infection: Screening and Management. J Clin Outcomes Manag. 21(1): 30—38. PMid:25554725 PMCid:PMC4279217

Lamont RF, Taylor-Robinson D, Bassett P. 2012. Rescreening for abnormal vaginal flora in pregnancy and re-treating with clindamycin vaginal cream significantly increases cure and improvement rates. Int J STD AIDS. 23(8): 565—569. http://dx.doi.org/10.1258/ijsa.2011.011229; PMid:22930293

Gubelin HW, Mart?nez TMA, C?spedes PP et al. 2006. Molecular detection of Mycoplasma genitalium in men and pregnant women. Rev Chilena Infectol. 23; 1: 15—19.

Qayum M, Khalidbin-Saleem M. 2013. Prevalence of Chlamydia trachomatis among asymptomatic women. J Ayub Med Coll Abbottabad. 25(1—2): 28—30. PMid:25098047

Mullick S, Watson-Jones D, Beksinska M et al. 2005. Sexually transmitted infections in pregnancy: prevalence, impact on pregnancy outcomes, and approach to treatment in developing countries. Sex Trans Infect. 81: 294—302. http://dx.doi.org/10.1136/sti.2002.004077; PMid:16061534 PMCid:PMC1745010

Suzuki Y, Yamamoto T, Kojima K. 2006. Evaluation levels of cytokines in amniotic fluid of women with intrauterine infection in the early second trimester. Fetal Diagn Ther. 21; 1: 45—50. http://dx.doi.org/10.1159/000089047; PMid:1635497

Leshem E, Maayan-Metzger A, Rahav G et al. 2012. Transmission of Staphylococcus aureus from mothers to newborns. Pediatr Infect Dis J. 31(4): 360—363. http://dx.doi.org/10.1097/INF.0b013e318244020e; PMid:22189535

Westhoff GL, Little SE, Caughey AB. 2011. Herpes simplex virus and pregnancy: a review of the management of antenatal and peripartum herpes infections. Obstet Gynecol Surv. 66(10): 629-638. http://dx.doi.org/10.1097/OGX.0b013e31823983ec; PMid:22112524

Workowsky KA, Berman S. 2010. Centers for Diseases Control and Prevention (CDS). Sexually Transmitted Diseases Treatment Guidelines. MMWR Recomm Rep. 59(RR-12): 1—10.