Вклад натурального ауто-IgM во врожденный иммунитет
DOI:
https://doi.org/10.15574/PP.2018.74.45Ключевые слова:
натуральные ауто-IgM антитела, иммунитет, В1-клеткиАннотация
Натуральные ауто-IgM синтезируются в B1-клетках (CD5+ мыши; CD20+CD27+CD43+CD70 — у людей) и играют существенную роль в защите организма от вторжения антигенов разного генеза, поддерживают иммунохимический гомеостаз организма, регулируя клиренс апоптических клеток, выполняют противовоспалительную функцию, регулируют аутореактивные антитела и удаляют протеины с незавершенным или дефектным фолдингом. Эти наблюдения стали толчком для поиска путей терапевтического применения натуральных ауто-IgM, увеличения их количества in vivo, а также применения моноклональных и поликлональных препаратов IgM.
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