Роль экологических и генетических факторов в формировании бронхиальной астмы у детей (обзор литературы)
DOI:
https://doi.org/10.15574/PP.2016.67.127Ключевые слова:
бронхиальная астма, генетика астмы, экология, детиАннотация
В статье представлен аналитический обзор литературы отечественных и зарубежных авторов по факторам риска развития бронхиальной астмы у детей. Состояние здоровья зависит от качества окружающей среды на 20–40%, а развитие бронхиальной астмы — от генетических факторов на 35–70%. Взаимодействие генетических факторов и факторов окружающей среди приводит к развитию антиоксидантного стресса, изменениям не только на уровне организма, но и на клеточном, молекулярном уровнях. Для оценки прогноза формирования и прогрессирования бронхиальной астмы у детей, проживающих в экологически неблагополучных регионах, необходимо продолжить изучение молекулярно)генетического полиморфизма генов ферментов системы детоксикации ксенобиотиков, а также метаболических нарушений у детей с целью выявления групп высокого риска по формированию заболевания и разработки показаний для антиоксидантной терапии, направленной на коррекцию молекулярных нарушений, формирующихся задолго до клинической манифестации болезни.
Ключевые слова: бронхиальная астма, генетика астмы, экология, дети.
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